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9.3.2008 1:53 PM

Gov. Panel Confirms Health Risk from Bisphenol-A

Chemical May Affect Prostate, Brain and the Development of Fetuses, Infants and Children

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Bisphenol A found in formula
Photo: Evangelos Patriarcheas / Istock

By Dan Shapley

Two weeks after the Food and Drug Administration declared the controversial plastics chemical Bisphenol-A safe, the National Toxicology Program has finalized its very different conclusion.

The NTP, part of the National Institute of Health, has "some concern" about Bisphenol-A — meaning that on a five-point scale, from no concern to very concerned, this chemical gets a three.

The panel restricted its analysis to the chemical's potential effects on reproduction and development. It consulted laboratory animal studies, some of which show health effects from the chemical at levels comparable to the levels that humans are exposed to.

The FDA, not the NTP, regulates the use of chemicals in commerce and food, however, so don't expect the government to take Bisphenol-A out of plastic anytime soon. The FDA will, however, take the FTP findings into account when it meets later this month to discuss its draft health assessment of Bisphenol-A.

"There remains considerable uncertainty whether the changes seen in the animal studies are directly applicable to humans, and whether they would result in clear adverse health effects," said NTP Associate Director John Bucher. "But we have concluded that the possibility that BPA may affect human development cannot be dismissed."

"We are expressing this level of concern because we see developmental changes occurring in some animal studies at BPA exposure levels similar to those experienced by humans," Bucher added.

Here's what the National Toxicology Program had to say:

There Is Some Concern Bisphenol-A:

  • affects the prostate gland
  • affects the brain
  • affects development of fetuses, infants and children

"Some Concern" indicates a 3 on a scale of 1 (negligible concern) to 5 (high concern).

There Is Minimal Concern Bisphenol-A:

  • affects the development of the mammary glands
  • accelerates puberty in females
  • affects the reproductive health of those who work with the chemical

"Minimal Concern" indicates a 2 on the 1-5 scale.

There Is Negligible Concern Bisphenol-A

  • causes fetal or neonatal mortality
  • causes birth defects
  • causes reduced birth weight or growth
  • affects the reproductive health of people who do not work with the chemical

"Negligible Concern" indicates a 1 on the 1-5 scale.

With the chemical still in wide use, what are people to do?

"Unfortunately, it is very difficult to offer advice on how the public should respond to this information," said Michael Shelby, director of the NIH's Center for the Evaluation of Risks to Human Reproduction. "More research is clearly needed to understand exactly how these findings relate to human health and development, but at this point we can't dismiss the possibility that the effects we're seeing in animals may occur in humans. If parents are concerned, they can make the personal choice to reduce exposures of their infants and children to BPA."

No. 7 plastic baby bottles, three- and five-gallon water bottles, certain food containers and other items, including the lining of cans, may contain Bisphenol-A.

This Bill Moyers Journal video offers great background on the issue:


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